This server identifies genes with expression patterns similar to those of genes in "positive" standards and distinct from those of genes in "negative" standards. To discover genes that are expressed in the kidney, for instance, the ideal positive standard would be made up of kidney expressed genes while the ideal negative standard would be made up of genes not expressed in the kidney.
The specificity of the standards determines the specificity of the predictions. By adjusting properties of the positive and negative standards, researchers can tailor the predictions to the molecular follow-up they wish to perform. This in silico nano-dissection webserver allows researchers to create highly-specific standards. These standards can then identify genes specifically expressed a cell lineage.