A standard is simply a list of genes expressed in a tissue or cell lineage of interest. Standards allow this webserver to estimate the probability that a gene is expressed in a tissue or cell-lineage of interest. This server identifies genes with expression patterns similar to genes in "positive" standards that are distinct from those of genes in "negative" standards. For example, to discover genes with novel podocyte expression patterns, podocyte specific genes would be the positive standard, and those specifically expressed in nearby lineages would be used in the negative standards.
By creating new standards, you can examine cell-lineages and tissues that are beyond the scope of current databases. These standards can also be built from internal and unpublished experimental results. This allows for an iterative process that utilizes existing literature evidence to be combined with genome-scale data to inform high specificity molecular experiments.